N-GAMMA-FMOC-GAMMA-AMINOBUTYRIC ACID
FMOC-GAMMA-ABU-OH
CAS: 116821-47-7
Molecular Formula: C19H19NO4
N-GAMMA-FMOC-GAMMA-AMINOBUTYRIC ACID - Names and Identifiers
| Name | FMOC-GAMMA-ABU-OH |
| Synonyms | Fmoc-γ-ABU-OH FMOC-GAMMA-ABU-OH RARECHEM EM WB 0021 FMOC-4-AMINOBUTANOIC ACID FMOC-Γ-ABU-OH FMOC-GABA-OH N-γ-Fmoc-γ-aminobutyricacid N-FMOC-DL-4-AMINO-BUTYRIC ACID N-GAMMA-FMOC-GAMMA-AMINOBUTYRIC ACID N-(9-FLUORENYLMETHOXYCARBONYL)-4-AMINOBUTYRIC ACID N-(9-FLUORENYLMETHOXYCARBONYL)-GAMMA-AMINOBUTANOIC ACID N-(9-FLUORENYLMETHYLOXYCARBONYL)-GAMMA-AMINOBUTYRIC ACID 4-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}butanoic acid N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-GAMMA-AMINOBUTYRIC ACID |
| CAS | 116821-47-7 |
| EINECS | 1533716-785-6 |
| InChI | InChI=1/C19H19NO4/c21-18(22)10-5-11-20-19(23)24-12-17-15-8-3-1-6-13(15)14-7-2-4-9-16(14)17/h1-4,6-9,17H,5,10-12H2,(H,20,23)(H,21,22) |
N-GAMMA-FMOC-GAMMA-AMINOBUTYRIC ACID - Physico-chemical Properties
| Molecular Formula | C19H19NO4 |
| Molar Mass | 325.36 |
| Density | 1.256±0.06 g/cm3(Predicted) |
| Melting Point | 172.0 to 176.0 °C |
| Boling Point | 571.9±33.0 °C(Predicted) |
| Flash Point | 299.7°C |
| Water Solubility | Slightly soluble in water. |
| Vapor Presure | 6.43E-14mmHg at 25°C |
| Appearance | White powder |
| Color | White |
| BRN | 7491485 |
| pKa | 4.68±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.6 |
| MDL | MFCD00144889 |
| Physical and Chemical Properties | Storage Conditions: 2-8 ℃ WGK Germany:3 |
N-GAMMA-FMOC-GAMMA-AMINOBUTYRIC ACID - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 2924 29 70 |
| Hazard Class | IRRITANT |
N-GAMMA-FMOC-GAMMA-AMINOBUTYRIC ACID - Introduction
4-(Fluorenylmethoxycarbonylamino) butyric acid, chemical formula C16H17NO3, also known as Fmoc-aminobutyric acid, is a commonly used protecting group in organic synthesis. It has the following properties:
1. Appearance: white or almost white crystalline powder.
2. Solubility: Good solubility in common organic solvents such as dimethylformamide (DMF), dichloromethane (DCM) and diphenyl ether.
3. Stability: It has good thermal stability and can withstand certain high temperature conditions during the synthesis process.
4. Reactivity: It can be esterified by the carboxyl group of the amino acid and the hydroxyl group on the fluorene group to introduce it into the target molecule.
The compound is mainly used for protecting hydroxyl groups in peptide synthesis. It can protect the hydroxyl group in the amino acid from being reacted in order to further synthesize the target peptide chain. At the end of the synthesis process, the Fmoc protecting group can be removed by basic conditions to give the free amino acid.
The method for preparing Fmoc-aminobutyric acid is mainly obtained by reacting fluorenyl chloroformate with butoxyamine.
Regarding safety, Fmoc-aminobutyric acid is relatively safe under general operating conditions, but the following aspects still need to be paid attention:
1. Avoid inhalation: When using this substance, it is recommended to maintain a well-ventilated laboratory environment and wear suitable protective equipment, such as safety masks and gloves.
2. Avoid skin contact: When contacting Fmoc-aminobutyric acid, rinse immediately with water and use a suitable skin protectant.
3. avoid eating: Fmoc-aminobutyric acid is a chemical and should not be ingested or eaten by mistake. If ingested, seek medical attention immediately and show the relevant information to the doctor.
1. Appearance: white or almost white crystalline powder.
2. Solubility: Good solubility in common organic solvents such as dimethylformamide (DMF), dichloromethane (DCM) and diphenyl ether.
3. Stability: It has good thermal stability and can withstand certain high temperature conditions during the synthesis process.
4. Reactivity: It can be esterified by the carboxyl group of the amino acid and the hydroxyl group on the fluorene group to introduce it into the target molecule.
The compound is mainly used for protecting hydroxyl groups in peptide synthesis. It can protect the hydroxyl group in the amino acid from being reacted in order to further synthesize the target peptide chain. At the end of the synthesis process, the Fmoc protecting group can be removed by basic conditions to give the free amino acid.
The method for preparing Fmoc-aminobutyric acid is mainly obtained by reacting fluorenyl chloroformate with butoxyamine.
Regarding safety, Fmoc-aminobutyric acid is relatively safe under general operating conditions, but the following aspects still need to be paid attention:
1. Avoid inhalation: When using this substance, it is recommended to maintain a well-ventilated laboratory environment and wear suitable protective equipment, such as safety masks and gloves.
2. Avoid skin contact: When contacting Fmoc-aminobutyric acid, rinse immediately with water and use a suitable skin protectant.
3. avoid eating: Fmoc-aminobutyric acid is a chemical and should not be ingested or eaten by mistake. If ingested, seek medical attention immediately and show the relevant information to the doctor.
Last Update：2024-04-10 22:29:15
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